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RedCloud Doses NSCLC Patient in China Trial of Next-Gen EGFR TK

publication date: Aug 29, 2022

Shanghai RedCloud Bio dosed the first patient in a China Phase I/II trial of its lead product, a next-gen EGFR TKI candidate for NSCLC with the C797S mutation that is resistant to other EGFR TKIS therapies. RedCloud uses structural pharmacology and computational approaches for small molecule drug discovery and development. H002 is a fourth-gen EGRF inhibitor discovered by RedCloud. In preclinical studies, the candidate showed broad-spectrum potency and high selectivity against EGFR mutations, including single, double and triple mutations. H0002 has also shown potent anti-tumor activity in an EGFR-positive brain metastases model. More details....

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