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Jacobio to Start Phase III Trial of Novel Combination in NSCLC with KRAS G12C Mutations

publication date: Feb 20, 2024

Jacobio Pharma was approved to start a China Phase III clinical trial of glecirasib, a KRAS G12C inhibitor, combined with the SHP2 inhibitor JAB-3312 as a first-line therapy for non-small cell lung cancer patients with KRAS G12C mutations. The company said JAB-3312 is the first SHP2 inhibitor to begin a Phase III study globally in combination with an KRAS G12C inhibitor. The combination will be compared to the current standard of care, a combination of an PD-1 antibody and chemotherapy. Jacobio, a Beijing-San Francisco biopharma, is developing the KRAS G12C inhibitor for several solid tumor cancers. More details....

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