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Denovo Starts Global Phase II Trial of Precision Medicine for Resistant Depression

publication date: Jul 29, 2022

Denovo Biopharma, a Hangzhou-San Diego precision medicine company, has started a global biomarker-guided Phase IIb clinical trial of its therapy for treatment resistant depression. DB104 (liafensine) is a first-in-class triple reuptake inhibitor targeting transporters for dopamine, serotonin and norepinephrine. Using its machine learning technology, the company discovered a novel genetic biomarker for DB104 efficacy. Denovo “rescues” drugs that did not meet their efficacy goals by finding a biomarker that defines a sub-population of patients in which the candidate is effective. Its DGM4 biomarker may be the first genetic biomarker-guided therapy for a mental health disorder. More details....<

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