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BioCity Plans Trial of TIM-3 mAb with AstraZeneca’s PD-L1 for Liver Cancer

publication date: Sep 29, 2023

BioCity Biopharma, headquartered in Wuxi, China, will conduct a China Phase Ib/II trial of its BC3402, a mAb targeting the T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), together with AstraZeneca's approved anti-PD-L1, Imfinzi (durvalumab). The trial will enroll patients with advanced hepatocellular carcinoma (HCC). BioCity believes BC3402 has the potential to be a best-in-class anti-TIM-3 mAb because it binds to multiple TIM-3 epitopes with a higher binding affinity than similar candidates. BioCity develops differentiated therapeutics for cancer and autoimmune disorders including chronic kidney diseases. More details....

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