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Ascletis Says PD-L1 Induces “Functional Cure” in CHB Patients

publication date: Jul 1, 2022

Hangzhou Ascletis Pharma reported that chronic hepatitis B patients experienced a “functional cure” after being treated with its PD-L1 antibody. In a Phase IIb clinical trial, 42.9% of chronic hepatitis B patients who received ASC22 (envafolimab) experienced a sustained HBsAg loss. In 2019, Ascletis acquired China rights to develop ASC22 for viral diseases from Suzhou Alphamab. The company has also started trials of the PD-L1 for HIV in China and the US. Ascletis’s initial project was Ganovo, an interferon-free therapy for hepatitis C virus, which was approved for China use in 2018. More details....

Stock Symbol: (HK: 1672)

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