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Zymeworks’ HER2 Bispecific Under Review in China for Rare HER2 Cancers

publication date: Jun 10, 2024

Vancouver’s Zymeworks announced that its BLA for zanidatamab, a HER2-targeted bispecific antibody, was accepted for review by China’s CDE as a second-line treatment for HER2-positive biliary tract cancer (BTC). Zanidatamab can simultaneously bind two non-overlapping epitopes of the HER2 receptor, known as biparatopic binding. In 2018, BeiGene acquired Asia Pacific rights to zanidatamab and several other Zymeworks candidates in a $1.1 billion agreement. Following a Phase IIb trial, Zymeworks and BeiGene filed the BLA, which triggered an $8 million milestone from to Zymeworks. More details....

Stock Symbol: (NSDQ: ZYME)

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