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Suzhou Zion Out-Licenses Brain-Penetrating HER2 Candidate to Roche in $680 Million Deal

publication date: May 9, 2023

Suzhou Zion Pharma out-licensed ex-China global rights for its lead HER2 candidate to Roche in a $680 million agreement ($70 million upfront). ZN-A-1041 is an oral selective tyrosine kinase inhibitor targeting the Human Epidermal Growth Factor Receptor 2 (HER2) that was designed to penetrate the blood-brain-barrier. Up to 50% of patients with HER2-positive metastatic breast cancer will develop brain metastasis over the course of the disease. Zion is conducting a Phase 1 trial of the candidate in China and the US, with trial details expected at the poster sessions during the ASCO meeting next month. More details....

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