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TransThera Starts China Combination Trial of Lead Drug in GI Cancers

publication date: May 26, 2021

TransThera, a clinical stage Nanjing biopharma, will partner with Roche to test a combination therapy for China patients with gastrointestinal tract cancers. The companies will conduct a trial of TransThera's TT-00420 and Roche's anti-PD-L1, Tencentriq (atezolizumab). TT-00420 is novel small molecule kinase inhibitor. In a Phase I trial it showed preliminary clinical benefits in Cholangiocarcinoma patients and other GI cancer patients. It also appears to modulate the tumor microenvironment, which makes it an attractive partner for checkpoint inhibitors in hard-to-treat solid tumors. More details....

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