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Sirnaomics Starts US Trial of siRNA Therapy for Liver Fibrosis

publication date: Apr 5, 2022

Sirnaomics, a Suzhou-Maryland siRNA company, dosed the first subject in a US Phase I trial of STP707, a systemic small interfering RNA therapeutic to treat liver fibrosis in primary sclerosing cholangitis. The drug is administered by IV.  STP707 is composed of two siRNA oligonucleotides targeting TGF-β1 and COX-2 mRNA. Over-expressions of TGF-β1 and COX-2 are thought to play regulatory roles in tumorigenesis. In preclinical studies, IV administration of STP707 caused knock-down of TGF-β1 and COX-2 gene expression in the liver and lung. More details....

Stock Symbol: (HK: 2257)

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