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Otsuka Acquires Jnana and its Rare Disease Therapy in $1.1 Billion Agreement

publication date: Aug 1, 2024

Japan’s Otsuka Pharmaceutical acquired Jnana Therapeutics, a Boston pharma, for $800 million plus up to $325 million in milestones. Jnana is developing a novel therapy to treat phenylketonuria (PKU), a rare kidney disease. Jnana’s JNT-517 is an allosteric small-molecule inhibitor of SLC6A19, a solute carrier that regulates amino acid reabsorption in the kidney. It has completed a Phase Ib/II trial demonstrating its tolerability. Otsuka believes JNT-517 could be a first-in-class oral treatment for PKU. In 2018, Otsuka acquired another Boston company, Visterra, which develops antibody drugs for autoimmune diseases. More details....

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