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Lynk Pharma Reports Third-Gen JAK Inhibitor Meets Safety Goals in Phase I Trial

publication date: Apr 4, 2023

Lynk Pharmaceuticals of Hangzhou said a China Phase I trial of its third-gen, intestinal-restricted JAK inhibitor showed the candidate has good safety, tolerability and pharmacokinetics. LNK01003 is an oral small molecule JAK inhibitor aimed at ulcerative colitis and related diseases. Its mechanism concentrates exposure of the drug in the gastrointestinal tract, which is expected to avoid systemic immunosuppression and reduce side effects. At the same time, Lynk says its candidate delivers increased amounts of the drug to gastrointestinal tissues, increasing the inhibitory effect on multiple inflammatory cytokines that cause IBD. More details....

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