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Leads’ Bispecific Effective in Extrapulmonary Neuroendocrine Carcinomas

publication date: Jun 4, 2024

Nanjing Leads Biolabs presented clinical data from a Phase I/II trial of LBL-024, a bispecific antibody composed of an anti- PD-L1 and an anti-4-1BB (CD137) antibody. The candidate showed efficacy as a monotherapy for patients with advanced malignant tumors, particularly extrapulmonary neuroendocrine carcinoma (EP-NEC) patients who had failed at least one line of chemotherapy. EP-NEC is a rare disease that usually occurs in the stomach, intestines and pancreas. Because the diagnosis is usually made at a late stage of the disease, the cancer has already metastasized, and the prognosis is poor. There is no approved therapy for EP-NEC. More details....

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