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Suzhou Kintor Starts US Trial of ALK-1 mAb for Hepatocellular Carcinoma

publication date: May 4, 2022

Suzhou Kintor Pharma dosed the first patient in a US Phase II trial of its ALK-1 antibody in combination with Opdivo (nivolumab) to treat advanced Hepatocellular Carcinoma. Kintor believes the ALK-1 antibody is a potential first-in-class, fully human IgG2 neutralizing mAb. It inhibits BMP9, TGFβ through ALK-1 receptor-mediated signal transduction and tumor angiogenesis. In 2018, Kintor acquired global rights to the ALK-1 antibody from Pfizer. The Phase II trial will enroll 105 patients who were intolerant of checkpoint inhibitors or progressed after a first-line round of checkpoint therapy. More details....

Stock Symbol: (HK: 9939)

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