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Kangpu Doses First Patient in Phase IIa Trial for Protein Degradation Therapy

publication date: Jun 14, 2022

Shanghai Kangpu Biopharma has dosed the first patient in a US Phase IIa clinical trial of KPG-818, an orally bioavailable NeoMIDESTM molecular glue being tested as a protein degradation therapy for systemic lupus erythematosus. In a US Phase Ib trial, KPG-818 demonstrated good tolerability, a favorable pharmacokinetic profile, and substantial potency for the degradation of Ikaros and Aiolos (IKZF1 and IKZF3). Kangpu Biopharma has built a pipeline of novel small molecular entities that modulate CRL4CRBN E3 ligase complex with potential to treat solid tumors, hematological malignancies, auto-immune diseases and inflammatory disorders. More details....

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