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InxMed Will Begin China Trial of FAPα Inhibitor to Lower Immunotherapy Resistance

publication date: Aug 30, 2023

Nanjing InxMed reported OMTX705, a first-in-class ADC targeting fibroblast-activating protein α (FAPα), was approved to start China trials. FAP is a type-II transmembrane serine protease expressed almost exclusively in pathological conditions including cancer, where it is expressed in cancer-associated fibroblasts (CAF) surrounding the tumor cells and microvasculature. InxMed, which focuses on resistance to oncology drugs, said FAP-expressing CAFs have been shown to play important roles in tumor drug resistance. The company in-licensed Asian commercial rights to OMTX705 from Spain’s Oncomatryx, a company developing novel drugs that target the tumor microenvironment. More details....

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