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InnoCare to Start BCL2 Inhibitor Trial in US for Hematological Cancers

publication date: Jan 16, 2024

Beijing InnoCare Pharma was approved to start US clinical trials for its B-cell lymphoma-2 (BCL2) inhibitor, ICP-248, the company’s fifth innovative candidate to start US trials. ICP-248 is an orally bioavailable BCL2-selective inhibitor that is expected to treat hematologic malignancies as a monotherapy or in combination with other therapies. The abnormal expression of BCL2, a regulatory protein of the apoptosis pathway, is related to the development of several hematologic malignancies. InnoCare has already started a Phase I dose escalation trial of ICP-248 is China, where preliminary results showed good efficacy and safety profiles. More details....

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