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Harbour BioMed Starts Australian Trial of CTLA-4 Checkpoint Inhibitor

publication date: Nov 4, 2019

Harbour BioMed, a Boston, Rotterdam and Shanghai biopharma, started the first clinical trial of a next-gen anti-CTLA-4 antibody (HBM4003) in patients with advanced solid tumors. The Australian trial is the first with a fully human antibody based on heavy chain only antibody technology (HCAb). The company said HBM4003 showed potent anti-tumor activity with lower systemic drug exposure in preclinical tests, potentially offering an improved therapeutic profile. The Australian trial will be followed by similar tests in China and the US. More details....

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