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Chugai Pharma Approved for China Launch of Complement Inhibitor 5 for NPH

publication date: Feb 13, 2024

Tokyo’s Chugai Pharma announced China approval of crovalimab, a humanized complement inhibitor C5 mAb to treat paroxysmal nocturnal hemoglobinuria (PNH).  It is the first approval of crovalimab anywhere in the world. A rare disease, PNH is an acquired life-threatening blood disease, characterized by the destruction of red blood cells, blood clots and impaired bone marrow function. Crovalimab uses Chugai’s Recycling Antibody technology, which allows a mAb to bind repeatedly to an antigen, enabling sustained complement inhibition at a low dose. Switzerland’s Roche owns 62% of Chugai. More details....

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