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Ascentage Reports 91% Response Rate for Bcl-2 Inhibitor in WM

publication date: Jun 5, 2024

Suzhou Ascentage Pharma reported an objective response rate of 90.9% in a global Phase Ib/II trial of its Bcl-2 inhibitor, lisaftoclax, in Waldenström macroglobulinemia (WM) patients who received a combination of lisaftoclax and Imbruvica, a Janssen-AbbVie BTK inhibitor. The combination was more than twice as effective than other regimens. Lisaftoclax was administered either as a monotherapy or in combination with other drugs in the trial’s treatment-naïve enrollees. Lisaftoclax is the first pivotal-stage Bcl-2 inhibitor in China. The data was presented at the American Society of Clinical Oncology Annual Meeting. More details....

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