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AriBio of South Korea Expands Phase III Trial of Alzheimer’s Therapy

publication date: Nov 15, 2023

South Korea’s AriBio has expanded a Phase III trial of its early Alzheimer’s disease therapy into the EU, UK, Korea and China. AR1001 (mirodenafil dihydrochloride) was originally developed as an erectile dysfunction therapy targeting phosphodiesterase 5. Similar to other PDE5 therapies, it has shown efficacy for AD, though the results have been spotty for the entire PDE5 class. AriBio says AR1001 is 10-fold more potent at inhibiting PDE5 and better at entering the brain than approved PDE5 inhibitors, including sildenafil. The Phase III study is a double-blind, randomized, placebo-controlled trial with efficacy/safety endpoints after 52 weeks of treatment in early-stage AD patients. More details....

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