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Apollomics Acquires Rights to Novel Iterion Oncology Candidate

publication date: Feb 11, 2021

Apollomics, a California-Hangzhou oncology company, acquired greater China rights to an Iterion candidate for desmoid tumors, a rare type of sarcoma that has no approved therapies. The candidate, tegavivint, inhibits nuclear β-catenin that binds to TBL1 (Transducin βeta-like Protein One), a downstream target in the Wnt-signaling pathway. Tegavivint is currently in a Phase I/IIa clinical trial in progressive desmoid tumors. It has also shown pre-clinical activity in acute myeloid leukemia and non-small cell lung cancer. Iterion, located in Houston, Texas, develops beta-catenin modulators for cancer. More details....

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