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Antengene Approved to Start Trial of Oral CD73 Inhibitor for Solid Tumors

publication date: Feb 7, 2022

Shanghai Antengene was approved to start an Australian Phase I trial of ATG-037, an oral small molecule CD73 inhibitor, in patients with advanced or metastatic solid tumors. As a primary objective, the study will evaluate the safety and tolerability of ATG-037 as a monotherapy and in combination with an immune checkpoint inhibitor. It will also determine the appropriate dose for Phase II studies and assess preliminary efficacy. CD73 is a target because it generates adenosine, which suppresses the immune system in the tumor microenvironment. The trial is a first-in-human study of the candidate. More details....

Stock Symbol: (HK: 6996)

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