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Antengene Awarded Orphan Status for Claudin 18.2 ADC in Two Cancer Indications

publication date: May 23, 2023

Shanghai Antengene announced the US FDA awarded two Orphan Drug Designations for ATG-022, a Claudin 18.2 antibody drug conjugate, one for gastric cancer and another for pancreatic cancer. Claudins are cell adhesion molecules normally expressed between cells to form a barrier that regulates cell permeability. In cancer, Claudins are expressed on the cell surface due to changes in cell polarity. The Claudin 18.2 isoform is overexpressed in gastric, esophageal and pancreatic cancers. ATG-022 has started Phase I trials in China and Australia. More details....

Stock Symbol: (HK: 6996)

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