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Antengene Doses First Patient in Trial of ERK1/2 Inhibitor Combined with BMS’s PD-1

publication date: Jul 18, 2023

Shanghai Antengene has dosed the first patient in a US Phase I combination trial of its small molecule ERK1/2 inhibitor (ATG-017) and nivolumab, a Bristol Myers Squibb PD-1 inhibitor marketed as Opdivo. The trial will enroll patients with advanced solid tumors. ATG-017 is an oral selective small molecule extracellular signal-regulated kinases 1 and 2 (ERK1/2) inhibitor. In preclinical studies, Antengene found that combining its ERK1/2 inhibitor with an immune checkpoint inhibitor produced improved efficacy in preclinical ICI-resistant in vivo murine models. More details....

Stock Symbol: (HK: 6995)

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