Akeso Approved for China Trial of Dual PD-1 Bi-Specifics Therapy

Akeso, a Hangzhou biopharma, was approved to start a China Phase Ib/II trial of a dual PD-1-based bi-specific therapy for advanced non-small cell lung cancer (NSCLC). The therapy will combine cadonilimab (PD-1/CTLA-4 bi-specific antibody), a first-in-class novel immunotherapy developed by Akeso, with ivonescimab (PD-1/VEGF bi-specific antibody), another Akeso candidate. Akeso said the trial is the world's first study of two combined bi-specific antibodies. Cadonilimab is already under review in China as a second-line therapy for cervical cancer. More details....

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