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ABM Therapeutics Begins China Phase I Trial of BRAF Inhibitor for Brain Tumors

publication date: Sep 5, 2023

ABM Therapeutics, a Shanghai-San Diego biopharma, dosed the first patient in a multicenter China Phase I study of its lead drug in patients with relapsed and drug resistant malignant brain tumors. ABM-1310 is a brain-penetrating small molecule next-gen BRAF inhibitor. In pre-clinical tests, the candidate showed promise for treating cancer metastases in the brain. ABM has two clinical trials of AMB-1310 already under way for BRAF V600X mutated solid tumors: a China trial for melanoma with brain mets and a US study for colorectal cancer. ABM develops small molecule drugs for brain cancers and brain metastases. More details....

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