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Sichuan Clover Doses First Patient in China Trial of Novel Cancer Biologic

publication date: Sep 10, 2019

Sichuan Clover Biopharma has dosed the first patient in a China Phase I trial of its fully-human TRAIL-Trimer fusion protein in cancer patients with peritoneal carcinomatosis. Clover described PC as a loco-regional disease defined as tumor dissemination inside the peritoneal cavity that often stems from gastrointestinal tumors. SCB-313 is a novel fusion protein consisting of TRAIL (TNF-related apoptosis-inducing ligand) and Clover's Trimer-Tag©, which allows the molecule to be trimerized. Clover believes its trimerized fusion proteins will be effective against previously undruggable targets.. More details....

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